No SSRI should be coadministered with a monoamine oxidase inhibitor. ( see Central serotonin syndrome above)

Fluoxetine and paroxetine are metabolized substantially be the CYP-2D6 enzyme pathway this means there is the possibility for drug interactions with other agents which are metabolized through this system.

The use of these tables is only a guide to suspect potential drug interactions. You should always consult the prescribing information before prescribing any drug.

Drugs metabolized through the CYP 3A3/4 system

Durgs metablized through the CYP-2D6 enzyme system
Analgesics acetaminophen, codiene, dextromethorphan Antiarrhythmics- encainamide, flecainide, mexiletine, propafenone
Antiarrhythmics amiodarone, disopyramide, lidocaine, propafenone, quinidine
Anticonvulsants carbamazepine, ethosuximide Antihypertensive- propranolol, metaprolol, timolol, alprenolol
Anitdepressants amitryptiline, clomipramine, imipramine, nefazadone, sertraline, norfluoxetine, fluvoxamine
Antiestrogens tamoxifen, docetaxel, paclitaxel Antidepressants- TCAs, fluoxetine, paroxetine, venlafaxine, mCPP (metabolite of nefazadone and trazadone)
Antihistamines astemizole, loratadine, terfenadine
Benzodiazepines Antipsychotics- haloperidol, risperidone, thioridazine, perphenazine, probably other phenothiazines as well
Calcium channel blockers nifedipine, verapamil, felodipine, diltiazem
Immunosuppressants cyclosporin
Local anesthetics cocaine, lidocaine Opiates- codiene, dextromethorphan, ethylmorphine
Antibiotics and antifungals ketoconazole, erythromycin, clarithromycin
Steroids Cortisol, dexamethasone, DHEA, estradiol, ethinylestradiol, progesterone, testosterone Others- phenformin, debrisoquin
other cisapride, dapsone, lovastatin, omeprazole