Pharmacokinetic Differences Between Different SSRIs

SSRI Plasma elimination half-life Linearity of
pharmacokinetics
single dose multiple dose
[active metabolite]

Paxil
10h.
21h.
Nonlinear

Luvox
11h.
14h.
Nonlinear

Zoloft
26h.
26h.
[36h.]
Linear

Celexa
33h.
33h.
Linear

Prozac
1.9 days
5.6 days
[7-15 days]

Nonlinear

nonlinear: half-life elimination is longer at higher plasma concentrations, due to autoinhibition of metabolism; Linear: half-life elimination does not depend on plasma concentration